Agouti-related Peptide (AgRP) in Healthy Mothers and Mothers With Preeclampsia and Their Offspring
The study is focused on the investigation of possible associations between plasma/serum levels of agouti related peptide (AgRP) and its genetic background in healthy women with physiological pregnancy (non-preeclamptic) and women with preeclampsia, in the postpartum period, and in their offspring.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Genotype-phenotype Associations of Agouti-related Peptide (AgRP) in Postpartum Period in Preeclamptic and Non-preeclamptic Women and Their Offspring|
- plasma/serum level of agouti/related peptide in peripheral blood in postpartum mother [ Time Frame: 2-4 hours postpartum ] [ Designated as safety issue: No ]
- Plasma level of agouti-related peptide in umbilical cord blood from the newborn [ Time Frame: immediately postpartum ] [ Designated as safety issue: No ]
- maternal weight gain during pregnancy [ Time Frame: using postpartum and peripartum data ] [ Designated as safety issue: No ]
- birth weight of the newborn [ Time Frame: immediately postpartum ] [ Designated as safety issue: No ]
- maternal preconceptional BMI [ Time Frame: anamnestic information ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
whole blood, umbilical blood
|Study Start Date:||January 2005|
|Study Completion Date:||December 2006|
|Primary Completion Date:||March 2006 (Final data collection date for primary outcome measure)|
Mothers with preeclampsia diagnosed according to the Guidelines by the Czech Society of obstetrics and gynecology as development of hypertension after the 20th week of pregnancy (systolic blood pressure, ≥140 mmHg; and/or diastolic blood pressure, ≥90 mmHg; measured at rest on two consecutive occasions at least 24 h apart) in previously normotensive women, and the onset of proteinuria (>300 mg of urinary protein/L over 24 h).
Newborns, physiological pregnancy-delivery
The newborns from the physiological pregnancies with spontaneous, uncomplicated delivery.
Newborns, pregnancy with preeclampsia
Newborns from the pregnancies complicated by preeclampsia.
Mothers, Physiological pregnancy-labour
The cohort of non-preeclamptic mothers with physiological, uncomplicated conception, pregnancy and delivery.
The study is focused on investigation of possible genotype-phenotype interactions of agouti-related peptide (AgRP) in postpartum non-preeclamptic women and preeclamptic women and in their offspring.
|Masaryk university affiliated hospital, Clinic of Obstetrics and Gynecology|
|Brno, Moravia, Czech Republic, 625 00|
|Principal Investigator:||Julie Bienertova-Vasku, MD.,, Ph.D.||Department of Pathological Physiology, Faculty of Medicine, Masaryk University|
|Study Director:||Anna Vasku, prof. Ph.D.||Department of Pathological Physiology, Faculty of Medicine, Masaryk University|
|Study Director:||Petr Bienert, Dr.||Department of Pathological Physiology, Faculty of Medicine, Masaryk University|